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Additional assistance for the idea that other targets In addition to COX-two are essential for celecoxib's anticancer consequences has come from studies with chemically modified variations of celecoxib. Various dozen analogs of celecoxib had been created with tiny alterations inside their chemical structures.[21] Many of these analogs retained COX-
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Quantification of NFY nuclear protein levels in untreated and INI-43–addressed cells is revealed relative to TBP in a similar extract. File, Western blot analyses exhibiting inhibition of Kpnβ1 expression working with siRNA and also a resultant very similar lessen in NFY nuclear localization as that observed applying INI-43.Subsequently, a serie